11-OXYGENATED ETHYNYL-, VINYL-, AND ETHYLTESTOSTERONES

Fully Delocalized (Ethynyl)(vinyl)phenylene-Bridged Diruthenium Radical Complexes

Florian Pevny, Emmanuel Di Piazza, Lucie Norel, Malte Drescher, Rainer F. Winter,* and St ephane Rigaut* Institut f€ ur Anorganische Chemie der Universit€ at Regensburg, Universit€ atsstrasse 31, D-93040 Regensburg, Germany, Fachbereich Chemie der Universit€ at Konstanz, Universit€ atsstrasse 10, D-78453 Konstanz, Germany, and UMR 6226 CNRS-Universit e de Rennes 1, Sciences Chimiques de Rennes,...

17α-Ethynyl-3-methoxy­estra-1,3,5(10),9(11)-tetraen-17-ol

In the title compound, C(21)H(24)O(2), rings B, C and D adopt half-chair, distorted half-chair and envelope conformations, respectively. In the crystal structure, there is an inter-molecular O-H⋯O hydrogen bond. The mol-ecules are arranged in a head-to-tail fashion, with the meth-oxy and hydr-oxy groups forming a two-dimensional hydrogen-bond network.

9-Ethynyl-9H-carbazole

The title compound, C(14)H(9)N, is the second crystallographically characterized example of an ynamine with an H atom in the C-terminal position. There are two independent mol-ecules (A and B) in the asymmetric unit. The structures of both mol-ecules are essentially planar (r.m.s. deviation = 0.0312 and 0.0152 Å). The N-C(sp) bond lengths are 1.353 (4) and 1.350 (4) Å, and those of the acetyl-e...

Metabolism of 11-oxygenated steroids. 1. Influence of the A/B ring junction on the reduction of 11-oxo groups.

11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome

Context Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to androgen excess in women with PCOS. Methods On...